Venoms coach Fred Kajoba is keen on seeing his side peel further away from defending champions KCCA.
STARTIMES UGANDA PREMIER LEAGUE
Wakiso Giants v Vipers (4pm)
URA v Police (4.30pm)
Tooro Utd v SC Villa (4pm)
The Venoms (53) could go six points clear on top of the league when they face Wakiso Giants on Friday at Kabaka Kyabaggu Stadium.
However, they will need to employ the same energy they applied in the 5-0 thumping of relegation-threated Maroons on Saturday at St Mary's Stadium Kitende.
Despite lying in 10th on 29 points, Wakiso Giants feel they are not safe yet and will be aiming for maximum points against the Venoms.
The Purple Sharks are keen on returning to winning ways, having lost their last game - against high-flying Busoga United in Jinja.
But the visitors will be boosted by the return of their forward, Tito Okello, who missed the Maroons game due to an injury he picked in the goalless draw with KCCA at Kitende last month.
Venoms coach Fred Kajoba is keen on seeing his side peel further away from the defending champions.
Mike Mutebi's side had a chance to close the gap at the summit but a 1-1 derby result against Proline on Tuesday left them three points behind.
Kajoba's side remain focused on a fourth league title.
Elsewhere, at the Arena of Visions in Ndejje, URA host a struggling Police side languishing in the drop zone on 22 points. They are 14th and level on points with Proline (15th) and Tooro United (16th).
With five games left to conclude the season, the Cops desperately need a win to offer them a chance of staying afloat.
URA have been a tough nut to crack at home. They have beaten the likes of KCCA, Vipers and SC Villa here this season. They were 2-1 winners over Express in their last game away at Muteesa II Stadium Wankuluku.
Police will be coming into Friday's game on the back of a 1-0 defeat by KCCA at Lugogo.
When the two sides met in the first round, the tax collectors emerged 1-0 winners at Lugogo.
So what does victory mean for each side?
URA, now in 5th place on 40 points, could move up to fourth or third depending on the margin of the win.
Police will climb out of the relegation zone with a win and settle in 13th place.