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Clashes erupted on Tuesday between the Sudanese regular army and the paramilitary Rapid Support Forces in Omdurman, Khartoum's twin city, the army said, calling the fighting part of a "large-scale" offensive.
Explosions rang out in the area, where the RSF had retreated after losing control of the Sudanese capital in March, an AFP correspondent at the scene reported.
The army said its operation was aimed at driving the paramilitaries, with which it has been at war since April 2023, from their last positions in Khartoum state.
The conflict has pitted the army headed by Sudan's de facto leader, Abdel Fattah al-Burhan, against the RSF under his former deputy, Mohamed Hamdan Daglo.
The conflict has effectively split the country in two, with the army controlling the north, east, and centre, while the RSF dominates nearly all of Darfur and parts of the south.
Besides killing tens of thousands of people, the two-year conflict has uprooted 13 million others, more than three million of whom have fled the country as refugees.