Asante Kotoko (GHA) v Kwara Utd (NGR), Generation Foot (SEN) v AFAD Djekanou (CIV), Bhantal (SLE) v Hafia (GUI), USFA (BUR) v Gbohloe-su des Lacs (TOG), Abia Warriors (NGR) v Djoliba (MLI), Nigelec (NIG) v Safi (MAR), Stade Tunisien (TUN) v Snim (MTN), Aigle Royal (CMR) v San Pedro (CIV), Black Man Warrior (LBR) v Coton (BEN), Dekadaha (SOM) v Al Zamala (SUD), Wolitta Dicha (ETH) v Al Ittihad (LBA), NEC (UGA) v Nairobi Utd (KEN), Al Ahly Madani (SUD) v Etoile Sahel (TUN), Port (DJI) v KMKM (ZAN), El Merriekh Bentiu (SSD) v AZAM (TAN), Flambeau Centre (BDI) v Al Akhdar (LBA), Rayon Sports (RWA) v Singida Black Stars (TAN), Foresters (SEY) v 15 Agosto (GEQ), FC 105 (GAB) v ZESCO Utd (ZAM), Mighty Wanderers (MAW) v Jwaneng Galaxy (BOT), T.B.C. (COD) v Djabal (COM), Kabuscorp (ANG) v Kaizer Chiefs (RSA), T.B.C. (COD) v Pamplemousses (MRI), Young Africans (NAM) v Royal Leopard (ESW), Ferroviario Maputo (MOZ) v Fanalamanga (MAD), Primeiro Agosto (ANG) v Otoho (CGO)
1st legs: Sept 19-21, 2nd legs: Sept 26-28
Byes: Zamalek, Al Masry (both EGY), Chabab Belouizdad, USM Alger (both ALG), Wydad Casablanca (MAR), Stellenbosch (RSA)
2nd rd
Kotoko or Kwara v Wydad, Generation or AFAD v USMA, Bhantal or Hafia v Belouizdad, USFA or Gbohloe-su v Abia or Djoliba, Nigelec or Safi v Tunisien or Snim, Aigle or Pedro v Warrior or Coton, Dekadaha or Zamala v Zamalek, Wolitta or Ittihad v Masry, NEC or Nairobi v Madani or Etoile, Port or KMKM v Bentiu or AZAM, Flambeau or Akhdar v Rayon or Singida, Foresters or Agosto v Stellenbosch, 105 or ZESCO v Wanderers or Galaxy, T.B.C. (COD) or Djabal v Kabuscorp or Chiefs, T.B.C. (COD) or Pamplemousses v Young Africans or Leopard, Ferroviario or Fanalamanga v Primeiro or Otoho
1st legs: Oct 17-19, 2nd legs: Oct 24-26
Note: 2nd rd winners qualify for group stage from Nov 21