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Arsenal are expected to be without defensive lynchpin Gabriel Magalhaes when they host London rivals Tottenham Hotspur on Sunday as Manchester City seek to keep up the pressure on the Premier League leaders.
Pep Guardiola's City could cut the Gunners' lead at the top of the table to just one point, at least for 24 hours, if they beat Newcastle on Saturday.
Reigning champions Liverpool desperately need a win after five defeats in their last six Premier League matches, while Rob Edwards takes charge of his first match as Wolves manager.
AFP Sport looks at three talking points ahead of this weekend's action:
Arteta's Gabriel conundrum
Arsenal boss Mikel Arteta has a major headache as he considers how to reshuffle his defence against Spurs in the likely absence of the injured Gabriel Magalhaes.

Liverpool's Dutch manager Arne Slot arrives ahead of kick-off in the UEFA Champions League, league phase football match between Liverpool and Real Madrid at Anfield in Liverpool, north west England on November 4, 2025.
Liverpool's hopes of a successful title defence appear to be over after five defeats in six games left them eight points behind leaders Arsenal.
Sports analytics company Opta puts the champions' chances of winning the league at just over seven percent, following their 3-0 humbling by Manchester City before the international break.
Liverpool face Nottingham Forest, the only team who beat them at home last season, on Saturday with Arne Slot's men desperate to put their recent woes behind them.
The Reds' issues have been well documented but Liverpool's biggest problem is their leaky defence, which has so far conceded at least two goals in six of their past seven league games.
Former Liverpool defender Jamie Carragher has warned the club could even miss out on Champions League qualification if they fail to strengthen their defence in the January transfer window.
Reports this week suggest they remain interested in signing Crystal Palace defender Marc Guehi after a deal collapsed on transfer deadline day, but Liverpool need an immediate improvement.
Howe looks for 'big response' from Newcastle
Newcastle are languishing in 14th spot in the Premier League, with just three wins this season, as they prepare to welcome Manchester City to St James' Park on Saturday.

Eddie Howe, Newcastle United Manager, shouts instructions from the sideline during the UCL League Stage match between Newcastle United and S.L. Benfica at St. James's Park in Newcastle, on October 21, 2025.