Cloned dog raises big questions on science

Aug 08, 2005

SOUTH Korea’s Woo-Suk Hwang has reached the highest peak of cloning and stem cell research, but critics say he has taken science onto slippery slope and raised alarming questions about interfering with life.

SOUTH Korea’s Woo-Suk Hwang has reached the highest peak of cloning and stem cell research, but critics say he has taken science onto slippery slope and raised alarming questions about interfering with life.

On Wednesday, when Hwang was all smiles as he put on a lab coat and frolicked with an Afghan hound puppy named Snuppy, the world’s first cloned dog, which he helped create.

The dog was named after Seoul National University, where Hwang’s lab has produced results that have put his team at the forefront of cloning and stem cell technology. And Because of their reproductive cycle, dogs are considered one of the most difficult animals in the world to clone.

In May, Hwang’s team made the news for research fulfilling one of the basic promises of cloning technology in stem cell research that a piece of skin could be taken from a patient to grow stem cells with that patient’s specific genetic material. The work has made him a national hero in South Korea, where the government will spend about $43m to fund new labs for him and help Hwang set up a worldwide stem cell bank.

The government also commissioned stamps showing the hope of his research, depicting a human egg, a man in a wheelchair and an image of him rising, walking and embracing a standing woman. Hwang has said he is not cloning human embryos, but using eggs harvested from human females, infusing them with genetic material, to create cells that can never become human beings.

“I firmly reject the term human cloning,” Hwang said in an interview with Reuters in May. “This is a scientific activity called somatic nuclear transfer and in no part does it involve the physiological process of fertilisation of eggs by sperm.”

Culture of life

Critics have mounted to the type of work being performed by Hwang. US president George Bush has said: “I worry about a world in which cloning becomes acceptable.” And the Catholic Church has theological qualms. Bush has worked to limit US funding for stem cell research.

Lee Chang-young, a member of the Bioethics Committee of Catholic Bishops’ Conference of Korea, said using human eggs from women donors was an affront to the culture of life.

“I urge Dr Hwang to focus on stem cell research rather than embryonic studies that involve human eggs,” he told Reuters, cautioning: “The more animals are cloned, the more possibilities there are of creating a cloned human.”
South Korea has banned human cloning, a stand Hwang supports. But the country sees great promise in being identified as the global hub of therapeutic cloning, which involves creating embryos for a supply of stem cells for research or therapy to develop cures for diseases ranging from diabetes to Parkinson’s.

Even though the country has one of the highest percentage of Christians of any Asian country, the conservative Christian vote is not a major factor in elections as it is in parts of the US. Stem cells are master cells that can be coaxed to develop in any cell tissue type in the body.

Hwang and his team said the process to produce Snuppy, involving a 1,095 reconstructed embryos being transferred into 123 surrogates to create two living dogs, shows just how difficult it is to conduct reproductive cloning.

He said the efficiency rate was just 1.6 percent and the other cloned dog died from pneumonia just 22 days after birth Gerald Schatten, a University of Pittsburgh genetics expert, who was part of the team that produced Snuppy, said the moral and ethical costs of producing a human clone were far too high.

“We call for a worldwide ban on human reproductive cloning, which is also unethical,” he told a news conference with Hwang on Wednesday.

Reuters

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