Klopp's side took the lead through Diogo Jota's second half strike after Brighton's Neal Maupay had missed a penalty in the first half.
Guardiola and Klopp have been outspoken advocates of the use of five substitutes
Portugal forward Jota has made an instant impact since joined the English champions from Wolve.
City are already five points behind Liverpool, albeit with a game in hand.
On a prolific night across Europe which also saw a rampant Borussia Moenchengladbach hit six in Ukraine
Brazilian midfielder Fabinho, filling in for the absent Virgil van Dijk and Joel Matip in central defence, limped off in the first half of Tuesday's Champions...
Everton is this season’s shocker, as they have bolted to the top of the table with 4 wins out of 4 games, thanks to their lead striker Dominic Calvert-Lewin....
Arteta's side were beaten 3-1 by the Reds in the league on Monday and they return to Anfield on Thursday for a League Cup fourth round tie.
Goals from Sadio Mane, Andy Robertson and Diogo Jota saw off the Gunners, who had won their opening two league games of the season.
The outcome of the match could have been very different had Mane not escaped with just a yellow card for an elbow on Kieran Tierney after just three minutes....
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