Scientist identify sex brain cells in males

By Ruth Nasejje

For the study, the researchers observed brain cell activity in more than 100 male mice that were mounting and fighting.

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Two groups of nerve cells may serve as "onoff switches" for male mating and aggression, a new study in rodents has revealed. These neurons appear to send signals between two parts of the brain — the back tip, or posterior, of the amygdala and the hypothalamus — that together regulate emotions, including fear, anxiety, and aggression.

Led by researchers at New York University (NYU) Grossman School of Medicine, the study showed that male mice struggled to have sex in experiments that blocked signals from one amygdala cell group that communicates with the hypothalamus (MPNsignaling cells).

When the same signals were instead bolstered, the animals were not only able to mate, but would repeatedly court unreceptive females, something they would not do normally.

Similarly, when the action of a second cell group in the amygdala that also communicates with the hypothalamus (VMHvlsignaling cells) was blocked, the rodents attacked unfamiliar males half as often.

When these same neurons were triggered, the mice became unusually aggressive, even attacking their female mates and familiar males.

"Our findings provide new insights into the crucial role played by the posterior amygdala in driving male social behaviours, like sex and aggression," lead study author Prof. Takashi Yamaguchi, a fellow at NYU Langone Health and its Neuroscience Institute, said.

Past research suggested the amygdala's role in regulating social behaviours, but until now, experts had not uncovered its precise role in sexual behaviours. Instead, researchers had focused on the neighbouring hypothalamus, where both the MPN and VMHvl structures are located, as the brain's regulator of mating and fighting.

The new investigation, published online on Monday in the journal Nature Neuroscience, is the first to uncover two distinct groups of cells that facilitate communication between the posterior amygdala and the parts of the hypothalamus responsible for sex and aggression, says Yamaguchi.

It also provides key evidence that the posterior amygdala exerts "tremendous" infl uence over social behaviour, he adds. For the study, the researchers observed brain cell activity in more than 100 male mice that were mounting and fighting.

The authors measured how often the nerve cells naturally fi red signals throughout the animals' day. They found that MPN-signaling cells were most active during sex, while VMHvl-signaling cells were most active during confrontations with other males.

For each of the two cell groups, the researchers then suppressed or activated the neurons and observed how often the mice attempted to mount a mate or attack a strange male placed in their enclosure.

"Our new understanding of which cells prompt sexual and aggressive behaviours should help us choose better brain targets as we design future treatments for psychiatric disorders," senior study investigator Proff Dayu Lin, at NYU Langone and its Neuroscience Institute, said.

Still, Lin cautions that much of the posterior amygdala's structure remains poorly understood and that researchers still need to determine how these fi ndings might translate to human brains. Her team also plans to study how the two groups of nerve cells interact in the brains of female rodents.