Zaina Nabatanzi had a brace for the Kyebando based side before Fallone Nahimana added the other.
Patrick Senfuka, Isaac Kirabira , Yasin Mugume , Hassan Musana scored for Saints.
The league strugglers had to wait until the dead of half time to find the opener through Mulangila.
In the reverse fixture, Saints and Soana shared the spoils at Kavumba Recreation Ground in Wakiso.
SC Villa will open a coordination office in Mbale
Synergy beat Wandegeya in the reverse fixture in Masaka.
The Saints opened the second round of the league in style with 3-1 thrashing of BUL at Namboole Stadium last week.
The Jogoos will take on Simba away at Bombo Barracks Grounds on Tuesday. When the two sides met in the first round of the league, they played to a goalless...
The hosts started strong and often troubled the visiting side. And their bright start saw them take the lead in the 15th minute.
Former Nigerian top scorer Mfom Udoh shot Enyimba into the lead on 34 minutes, converting from the penalty spot.
Sign up to receive our free newsletter