National
New breast cancer gene mutation found to raise risk
Publish Date: Aug 11, 2014
New breast cancer gene mutation found to raise risk
  • mail
  • img
newvision

WASHINGTON - A newly discovered gene mutation significantly raises a woman's risk of breast cancer and may be considered the third such inherited gene flaw known to science, researchers.

Women with mutations in the PALB2 gene face a one in three chance of getting breast cancer by age 70, said the findings in the New England Journal of Medicine.

The other two known gene mutations associated with breast cancer risk, BRCA1 and BRCA2, have been linked to a 55-65 percent likelihood of developing breast cancer by age 70.

"Since the BRCA1 and BRCA2 mutations were discovered in the mid-90s, no other genes of similar importance have been found and the consensus in the scientific community if more exist we would have found them by now," said lead author Marc Tischkowitz from the Department of Medical Genetics at the University of Cambridge.

"PALB2 is a potential candidate to be 'BRCA3'."

Most cases of breast cancer are not passed down in families.

Only about five to 10 percent of all breast cancer has been linked to BRCA1 and BRCA2 gene mutations, according to the National Cancer Institute.

It remains unclear how prevalent PALB2 is in the general population, but researchers suspect it is rare.

The research in the New England Journal of Medicine was part of an international collaboration between 17 different institutions in eight countries.

Scientists analyzed data from 154 families without BRCA1 or BRCA2 mutations, which included 362 family members with PALB2 gene mutations.

Women with rare mutations in PALB2 were found to have on average a 35 percent chance of developing breast cancer.

Individual risk varied, however. Those with more cases of breast cancer in the family found themselves at higher risk.

PALB2 was first linked to breast cancer in 2007.

"Now that we have identified this gene, we are in a position to provide genetic counseling and advice," added Tischkowitz.

"If a woman is found to carry this mutation, we would recommend additional surveillance, such as MRI breast screening."

RELATED STORIES:

Men also develop breast cancer

Breast cancer on the rise

Keep the fire burning after breast cancer

Red meat consumption linked to breast cancer

The statements, comments, or opinions expressed through the use of New Vision Online are those of their respective authors, who are solely responsible for them, and do not necessarily represent the views held by the staff and management of New Vision Online.

New Vision Online reserves the right to moderate, publish or delete a post without warning or consultation with the author.Find out why we moderate comments. For any questions please contact digital@newvision.co.ug

  • mail
  • img
blog comments powered by Disqus
Also In This Section
Army tracks Ugandan rebels after DR Congo massacre
The Congolese army on Wednesday searched for suspected Ugandan rebels in villages in the east of the Democratic Republic of Congo, following the massacre of around 100 people last week, the UN said....
Museveni, Uhuru top African influential Presidents list
President Yoweri Museveni has been named among the four most influential Presidents on the African continent who feature on the list of the most influential persons on the continent....
PM hails Uganda’s relations with France, Germany
The Prime Minister, Dr. Ruhakana Rugunda, has applauded the level of trust, co-operation and brotherhood that exist between France, Germany and Uganda....
Reduce fertility rate to boost economic development – experts
The government should put in place effective measures to reduce the runaway fertility rate if it is to reap the benefits of demographic dividend, population experts have warned....
KCCA urged on reforms to protect women and children
Women activists are demanding reforms in the KCCA enforcement policy to ensure the safety of Ugandans – especially women and children – in public spaces....
Uganda, Saudi ties shaky after maid abuse video
A video of a Ugandan maid abusing a child that was uploaded by a diplomat from the Saudi Embassy in Uganda has gone viral....
Should Govt lease parts of Lake Victoria to private developers?
Its Ok
No Way
Not Sure
follow us
subscribe to our news letter